Mitochondrial base editing for disease modeling and therapeutic correction (Review)

Seongho Hong*, Sanghun Kim*, Je Kyung Seong, Youngho Kim and Hyunji Lee†.

Genome Biology, 2026 Aug 13;

IF=9.2

Papers

* : Equally Contributed
† : Corresponding Author

Protocol for non-invasive delivery of CRISPR RNPs via virus-like particles for mouse model generation

Da Eun Yoon*, Jiyun Yang*, Tae Yeong Jeong*, Jeongeun Park, Hyunji Lee, Je Kyung Seong, Kyoungmi Kim†

STAR Protocols, 2026 Mar 20;

IF=1.3

In Vivo Mitochondrial Base Editing Restores Genotype and Visual Function in a Mouse Model of LHON

Sanghun Kim, Jieun Kim, Seongkwang Cha, Sungjin Ju, Chae Jin Lim*, Seongho Hong, Jiyoung Bae, Yeji Oh, Sungmo Jung, Sol Pin Kim, Hae-Sol Shin, Jae Hee Yoon, Jeeyoon Park, Seungmin Ryou, Soo-Yeon Lim, Su Bin Lee, Seung Hee Choi, Soo-ji Park, Chang Geun Choi, Mihyun Choi, Lark Kyun Kim, Jiyoon Park, Seonghyun Lee†, Kyoung Yul Seo†, Je Kyung Seong†, Kyoungmi Kim†, Jin-Soo Kim†, and Hyunji Lee†.
Nature communications, 2025 Nov 23;
IF=15.7

Alterations in mitochondrial base editors enhance targeted editing efficiency for mouse model generation

Seongho Hong, Sol Pin Kim, Sanghun Kim, Soo Kyung Kang, Sungmo Jung, Yeji Oh, Seung Hee Choi, Su Bin Lee, Hou Cha, Jieun Kim, Jiyoung Bae, Jiyoon Park, Kyoungmi Kim, Chang Geun Choi, Soo-Ji Park, Do Hyun Kim, Lark Kyun Kim, Je Kyung Seong† and Hyunji Lee†.
Molecular Therapy Nucleic Acids 2025 Sep 9;
IF=6.1

An innovative approach using CRISPR-ribonucleoprotein packaged in virus-like particles to generate genetically engineered mouse models

Tae Yeong Jeong, Da Eun Yoon, Sol Pin Kim, Jiyun Yang, Soo-Yeon Lim, Sungjin Ok, Sungjin Ju, Jeongeun Park, Su Bin Lee, Soo-Ji Park, Sanghun Kim, Hyunji Lee, Daekee Lee, Soo Kyung Kang, Seung Eun Lee, Hyeon Soo Kim, Je Kyung Seong† and Kyoungmi Kim†.
Nature Communications 2025 Apr 11;
IF=14.7

Comprehensive phenotypic assessment of nonsense mutations in mitochondrial ND5 in mice

Sanghun Kim, Seul Gi Park, Jieun Kim, Seongho Hong, Sang-Mi Cho, Soo-Yeon Lim, Eun-Kyoung Kim, Sungjin Ju, Su Bin Lee, Sol Pin Kim, Tae Young Jeong, Yeji Oh, Seunghun Han, Hae-Rim Kim, Taek Chang Lee, Hyoung-Chin Kim, Won Kee Yoon, Tae Hyeon An, Kyoung-jin Oh, Ki-Hoan Nam†, Seonghyun Lee†, Kyoungmi Kim†, Je Kyung Seong† and Hyunji Lee†.
Experimental and Molecular Medicine 2024 Nov 1;
IF=12.9

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA

Sung-Ik Cho, Kayeong Lim, Seongho Hong*, Jaesuk Lee, Annie Kim, Chae Jin Lim, Seungmin Ryou, Ji Min Lee, Young Geun Mok, Eugene Chung, Sanghun Kim, Seunghun Han, Sang-Mi Cho, Jieun Kim, Eun-Kyoung Kim, Ki-Hoan Nam, Yeji Oh, Minkyung Choi, Tae Hyeon An, Kyoung-Jin Oh, Seonghyun Lee† and Hyunji Lee† and Jin-Soo Kim†.
Cell 2024 Jan 4;
IF=66.85

Precise Base Editing Without Unintended Indels in Human Cells and Mouse Primary Myoblasts

Da Eun Yoon, Na-Rae Kim, Soo-Ji Park, Tae Yeong Jeong, Bokkee Eun, Yongcheol Cho, Soo-Yeon Lim, Hyunji Lee, Je Kyoung Seong and Kyoungmi Kim†.
Experimental and Molecular Medicine 2023 Dec 1; IF=12.172

Recent Research Trends in Stem Cells Using CRISPR/Cas-Based Genome Editing Methods (Review)

Da Eun Yoon, Hyunji Lee† Kyoungmi Kim†.
International Journal of Stem Cells 2023 Oct 31;
IF=3.011

Clinical Approaches for Mitochondrial Diseases (Review)

Seongho Hong, Sanghun Kim, Kyoungmi Kim†, Hyunji Lee†.
Cells 2023 Oct 20; 12,2494
IF=7.666

Trends and prospects in mitochondrial genome editing (Review)

Hong Thi Lam Phan, Hyunji Lee† and Kyoungmi Kim†.
Experimental and Molecular Medicine 2023 May 1;
IF=12.172

Enhanced mitochondrial DNA editing in mice using nuclear exported TALE-linked deaminases and nucleases

Seonghyun Lee, Hyunji Lee, Gayoung Baek, Eunji Namgung, Joo Min Park, Sanghun Kim, Seongho Hong and Jin-Soo Kim.
Genome Biology 2022 Oct 12; 23:211
IF=17.906

Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors

Seonghyun Lee, Hyunji Lee, Gayoung Baek and Jin-Soo Kim.
Nature Biotechnology 2022 Oct 13; 41:378-386
IF=68.164

Chloroplast and mitochondrial DNA editing in plants

Beum-Chang Kang, Su-Ji Bae, Seonghyun Lee, Jeong Sun Lee, Annie Kim, Hyunji Lee, Gayoung Baek, Huiyun Seo, Jihun Kim and Jin-Soo Kim.
Nature Plants 2021 July 01; 7:899–905,
IF=17.352

Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor

Soo-Ji Park, Tae Yeong Jeong, Seung Kyun Shin*, Da Eun Yoon, Soo-Yeon Lim, Sol Pin Kim, Jungmin Choi, Hyunji Lee, Jeong-Im Hong, Jinhee Ahn, Je Kyung Seong† and Kyoungmi Kim†.
Genome Biology 2021 Jun 03; 22:170,
IF=17.906

Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

Hyunji Lee, Seonghyun Lee, Gayoung Baek, Annie Kim, Beum-Chang Kang, Huiyun Seo and Jin-Soo Kim.
Nature Communications 2021 Feb 19; 12:1190,
IF=17.69

STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells

Hyunji Lee, Hyunjung Chin, Hyeyoung Kim, Hosung Jung, Daekee Lee.
Molecular Oncology 2020 Jun 29; 14(8):1850-1867,
IF=6.603

Genome editing methods in animal models (Review)

Hyunji Lee, Da Eun Yoon, Kyoungmi Kim.
Animal Cells and Systems 2020 Feb 17; 24(1):8-16,
IF=2.34

Unexpected CRISPR on-target effects (Review)

Hyunji Lee & Jin-Soo Kim.
Nature Biotechnology 2018 July 30; 36:703-704,
IF=68.164

Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy

Seuk-Min Ryu, Taeyoung Koo, Kyoungmi Kim, Kayeong Lim, Gayoung Baek, Sang-Tae Kim, Heon Seok Kim, Da-eun Kim, Hyunji Lee, Eugene Chung & Jin-Soo Kim.
Nature Biotechnology 2018 Apr 27; 36:536-539,
IF=68.164

Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon

So-young Lee, Hwain Kim, Kyoungmi Kim, Hyunji Lee, Seungbok Lee & Daekee Lee.
Scientific Reports. 2016 May 27; 6:26923
IF=4.996

ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells

Hyunji Lee, Hyunjung Lee, Hyunjung Chin, Kyoungmi Kim and Daekee Lee.
Oncotarget. 2014 Jul 15; 5:5138-5152
IF=6.359

Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary

Kyoungmi Kim, Hyunji Lee, David W. Threadgill, Daekee Lee.
Biochem Biophys Res Commun. 2011 Feb 11; 405(2):319-24.
IF=3.575